Professor Gonçalo Bernardes FUUÂãÁÄÖ±²¥
Winner: 2024 Corday-Morgan Mid-Career Prize for Chemistry
University of Cambridge
For the design, development and application of targeted therapeutics including small molecule-based RNA degradation and conditional activation of chemotherapeutics.
Celebrate Professor Gonçalo Bernardes
Chemistry is central to biology, and I believe it is the greatest tool to decipher disease biology at the molecular level, which will then inform how to create next-generation therapeutics that are specific to diseased cells and not harmful to healthy cells.
The Bernardes group bridges the gap between organic chemistry and biology to unlock fundamental biological knowledge and pave the way for the next generation of targeted therapeutics.
In chemistry, the term 'chemoselectivity' refers to the ability of a reagent (a substance or compound that triggers a reaction) to single out a specific chemical group, ignoring other reaction pathways. Organic chemists have exploited this property to develop new catalysts and streamline the chemical synthesis of complex synthetic targets. Chemical biology takes this a step further. The group use this background in organic chemistry to harness the inherent reactivity of functional groups within biological macromolecules like DNA, RNA, and proteins to create biological probes and novel therapeutic agents.
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